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Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
Caspase-8 activity controls the switch from cell death to pyroptosis when apoptosis and necroptosis are blocked, yet how caspase-8 inactivation induces inflammasome assembly remains unclear. We show that caspase-8 inhibition via IETD treatment in Toll-like receptor (TLR)–primed Fadd(−/−)Ripk3(−/−) m...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651862/ https://www.ncbi.nlm.nih.gov/pubmed/36367942 http://dx.doi.org/10.1126/sciadv.abn9912 |