Feasibility of a Pragmatic PBPK Modeling Approach: Towards Model-Informed Dosing in Pediatric Clinical Care

BACKGROUND AND OBJECTIVE: More than half of all drugs are still prescribed off-label to children. Pharmacokinetic (PK) data are needed to support off-label dosing, however for many drugs such data are either sparse or not representative. Physiologically-based pharmacokinetic (PBPK) models are increa...

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Detalles Bibliográficos
Autores principales: van der Heijden, Joyce E. M., Freriksen, Jolien J. M., de Hoop-Sommen, Marika A., van Bussel, Lianne P. M., Driessen, Sander H. P., Orlebeke, Anne E. M., Verscheijden, Laurens F. M., Greupink, Rick, de Wildt, Saskia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651907/
https://www.ncbi.nlm.nih.gov/pubmed/36369327
http://dx.doi.org/10.1007/s40262-022-01181-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651907/
https://www.ncbi.nlm.nih.gov/pubmed/36369327
http://dx.doi.org/10.1007/s40262-022-01181-8

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