A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies

The safety of most human recombinant proteins can be evaluated in transgenic mice tolerant to specific human proteins. However, owing to insufficient genetic diversity and to fundamental differences in immune mechanisms, small-animal models of human diseases are often unsuitable for immunogenicity t...

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Detalles Bibliográficos
Autores principales: Flisikowska, Tatiana, Egli, Jerome, Flisikowski, Krzysztof, Stumbaum, Marlene, Küng, Erich, Ebeling, Martin, Schmucki, Roland, Georges, Guy, Singer, Thomas, Kurome, Mayuko, Kessler, Barbara, Zakhartchenko, Valeri, Wolf, Eckhard, Weber, Felix, Schnieke, Angelika, Iglesias, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652145/
https://www.ncbi.nlm.nih.gov/pubmed/36138193
http://dx.doi.org/10.1038/s41551-022-00921-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652145/
https://www.ncbi.nlm.nih.gov/pubmed/36138193
http://dx.doi.org/10.1038/s41551-022-00921-2

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