Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates

BACKGROUND AND OBJECTIVE: Previously, we developed a pharmacokinetic-pharmacodynamic model of allopurinol, oxypurinol, and biomarkers, hypoxanthine, xanthine, and uric acid, in neonates with hypoxic-ischemic encephalopathy, in which high initial biomarker levels were observed suggesting an impact of...

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Detalles Bibliográficos
Autores principales: Chu, Wan-Yu, Allegaert, Karel, Dorlo, Thomas P. C., Huitema, Alwin D. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652176/
https://www.ncbi.nlm.nih.gov/pubmed/36040612
http://dx.doi.org/10.1007/s40262-022-01164-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652176/
https://www.ncbi.nlm.nih.gov/pubmed/36040612
http://dx.doi.org/10.1007/s40262-022-01164-9

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