Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

BACKGROUND: Cytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter the exposure of CYP3A substrates. However, effects of such drug-drug interactions are usually reported as maximum effects rather than studied as time-dependent proc...

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Detalles Bibliográficos
Autores principales: Nassar, Yomna M., Hohmann, Nicolas, Michelet, Robin, Gottwalt, Katharina, Meid, Andreas D., Burhenne, Jürgen, Huisinga, Wilhelm, Haefeli, Walter E., Mikus, Gerd, Kloft, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652212/
https://www.ncbi.nlm.nih.gov/pubmed/36195807
http://dx.doi.org/10.1007/s40262-022-01175-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652212/
https://www.ncbi.nlm.nih.gov/pubmed/36195807
http://dx.doi.org/10.1007/s40262-022-01175-6

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