A nascent peptide code for translational control of mRNA stability in human cells

Stability of eukaryotic mRNAs is associated with their codon, amino acid, and GC content. Yet, coding sequence motifs that predictably alter mRNA stability in human cells remain poorly defined. Here, we develop a massively parallel assay to measure mRNA effects of thousands of synthetic and endogeno...

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Detalles Bibliográficos
Autores principales: Burke, Phillip C., Park, Heungwon, Subramaniam, Arvind Rasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652226/
https://www.ncbi.nlm.nih.gov/pubmed/36369503
http://dx.doi.org/10.1038/s41467-022-34664-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652226/
https://www.ncbi.nlm.nih.gov/pubmed/36369503
http://dx.doi.org/10.1038/s41467-022-34664-0

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