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Computationally designed GPCR quaternary structures bias signaling pathway activation

Communication across membranes controls critical cellular processes and is achieved by receptors translating extracellular signals into selective cytoplasmic responses. While receptor tertiary structures can be readily characterized, receptor associations into quaternary structures are challenging t...

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Detalles Bibliográficos
Autores principales: Paradis, Justine S., Feng, Xiang, Murat, Brigitte, Jefferson, Robert E., Sokrat, Badr, Szpakowska, Martyna, Hogue, Mireille, Bergkamp, Nick D., Heydenreich, Franziska M., Smit, Martine J., Chevigné, Andy, Bouvier, Michel, Barth, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652377/
https://www.ncbi.nlm.nih.gov/pubmed/36369272
http://dx.doi.org/10.1038/s41467-022-34382-7