Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain

Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epigenetic change have remained unclear. To address this knowledge gap, we probed chromatin acc...

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Detalles Bibliográficos
Autores principales: Zhang, Yanxiao, Amaral, Maria Luisa, Zhu, Chenxu, Grieco, Steven Francis, Hou, Xiaomeng, Lin, Lin, Buchanan, Justin, Tong, Liqi, Preissl, Sebastian, Xu, Xiangmin, Ren, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652396/
https://www.ncbi.nlm.nih.gov/pubmed/36207411
http://dx.doi.org/10.1038/s41422-022-00719-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652396/
https://www.ncbi.nlm.nih.gov/pubmed/36207411
http://dx.doi.org/10.1038/s41422-022-00719-6

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