Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

Mast cells (MC) are key drivers of allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-6 is an immunoregulatory receptor found on MCs. While it is recognized that engaging Siglecs with antibodies mediates inhibition across immune cells, the mechanisms that gov...

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Detalles Bibliográficos
Autores principales: Schanin, Julia, Korver, Wouter, Brock, Emily C., Leung, John, Benet, Zachary, Luu, Thuy, Chang, Katherine, Xu, Alan, De Freitas, Naomi, Luehrsen, Kenneth, Brehm, Michael A., Wong, Alan, Youngblood, Bradford A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652399/
https://www.ncbi.nlm.nih.gov/pubmed/36369358
http://dx.doi.org/10.1038/s42003-022-04207-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652399/
https://www.ncbi.nlm.nih.gov/pubmed/36369358
http://dx.doi.org/10.1038/s42003-022-04207-w

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