Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5

The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements that control the expressio...

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Detalles Bibliográficos
Autores principales: Collins, Joseph M., Nworu, Adaeze C., Mohammad, Somayya J., Li, Liang, Li, Chengcheng, Li, Chuanjiang, Schwendeman, Ethan, Cefalu, Mattew, Abdel‐Rasoul, Mahmoud, Sun, Jessie W., Smith, Sakima A., Wang, Danxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652438/
https://www.ncbi.nlm.nih.gov/pubmed/36045613
http://dx.doi.org/10.1111/cts.13398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652438/
https://www.ncbi.nlm.nih.gov/pubmed/36045613
http://dx.doi.org/10.1111/cts.13398

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