Cargando…

Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance

Multidrug resistance (MDR) has been restricting the efficacy of chemotherapy, which mainly include pump resistance and non-pump resistance. In order to fight overall MDR, a novel targeted gene/drug co-deliver nano system is developed, which can suppress the drug efflux pumps and modulate autophagy t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Changduo, Li, Zhipeng, Xu, Ping, Xu, Lisa, Han, Shangcong, Sun, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652912/ https://www.ncbi.nlm.nih.gov/pubmed/36369077 http://dx.doi.org/10.1186/s12951-022-01689-y

Ejemplares similares

Inhibition of MDR1 expression with altritol-modified siRNAs
por: Fisher, Michael, et al.
Publicado: (2007)

Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
por: Bi, Ye, et al.
Publicado: (2018)

Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy
por: Gladkikh, Daniil V., et al.
Publicado: (2021)

The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy
por: Patutina, Olga A, et al.
Publicado: (2010)

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene
por: Chernikov, Ivan V., et al.
Publicado: (2017)

Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment
por: Wang, Dandan, et al.
Publicado: (2017)

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer
por: Zhang, Xiangyang, et al.
Publicado: (2022)

Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors
por: Zeng, Xianhu, et al.
Publicado: (2021)

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors
por: Yang, Xin, et al.
Publicado: (2021)

Predicting siRNA efficacy based on multiple selective siRNA representations and their combination at score level
por: He, Fei, et al.
Publicado: (2017)

Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma
por: Susa, Michiro, et al.
Publicado: (2010)

Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer
por: Wu, Jun, et al.
Publicado: (2021)

Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer
por: Nourbakhsh, Mahnaz, et al.
Publicado: (2015)

Recent advances in anti-multidrug resistance for nano-drug delivery system
por: Wang, Changduo, et al.
Publicado: (2022)

Layered Double Hydroxide Modified with Deoxycholic and Hyaluronic Acids for Efficient Oral Insulin Absorption
por: Huang, Xia, et al.
Publicado: (2021)

Codelivery of Doxorubicin and MDR1-siRNA by Mesoporous Silica Nanoparticles-Polymerpolyethylenimine to Improve Oral Squamous Carcinoma Treatment [Corrigendum]
Publicado: (2021)

Comparison of characteristics and mortality in multidrug resistant (MDR) and non-MDR tuberculosis patients in China
por: Sun, Yanni, et al.
Publicado: (2015)

The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
por: Wolfensberger, Aline, et al.
Publicado: (2019)

Multidrug resistance (mdr) genes in human cancer.
por: Nooter, K., et al.
Publicado: (1991)

Multistage rocket: integrational design of a prodrug-based siRNA delivery system with sequential release for enhanced antitumor efficacy
por: Jiang, Qian, et al.
Publicado: (2018)

Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect
por: Chen, Enrui, et al.
Publicado: (2020)

Doxorubicin combined with Notch1-targeting siRNA for the treatment of gastric cancer
por: Zhou, Wei, et al.
Publicado: (2018)

Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA
por: Yingyuad, Peerada, et al.
Publicado: (2014)

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition
por: Berezhnoy, Alexey, et al.
Publicado: (2012)

Where should siRNAs go: applicable organs for siRNA drugs
por: Ahn, Insook, et al.
Publicado: (2023)

Targeted Delivery of siRNA Therapeutics to Malignant Tumors
por: Leng, Qixin, et al.
Publicado: (2017)

Low-dose amikacin in the treatment of Multidrug-resistant Tuberculosis (MDR-TB)
por: Sabur, Natasha F., et al.
Publicado: (2021)

Overcoming multidrug resistance through inhalable siRNA nanoparticles-decorated porous microparticles based on supercritical fluid technology
por: Xu, Pei-Yao, et al.
Publicado: (2018)

Chemosensitivity enhanced by autophagy inhibition based on a polycationic nano-drug carrier
por: Li, Na, et al.
Publicado: (2021)

Effects of polymer carriers on the occurrence and development of autophagy in drug delivery
por: Wang, Changduo, et al.
Publicado: (2022)

Atelocollagen-mediated in vivo siRNA transfection in ovarian carcinoma is influenced by tumor site, siRNA target and administration route
por: Meryet-Figuière, Matthieu, et al.
Publicado: (2017)

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
por: Xu, Haoyue, et al.
Publicado: (2022)

Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925
por: Yang, X, et al.
Publicado: (2014)

Predictors of Multidrug-Resistant Tuberculosis (MDR-TB) in Sudan
por: Ali, Monadil H., et al.
Publicado: (2019)

Image-Based Genome-Wide siRNA Screen Identifies Selective Autophagy Factors
por: Orvedahl, Anthony, et al.
Publicado: (2011)

Ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells
por: He, Yun, et al.
Publicado: (2011)

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer
por: Yang, Xiaoqian, et al.
Publicado: (2015)

PLGA nanoparticles co-delivering MDR1 and BCL2 siRNA for overcoming resistance of paclitaxel and cisplatin in recurrent or advanced ovarian cancer
por: Risnayanti, Chitra, et al.
Publicado: (2018)

Tumor-specific delivery of therapeutic siRNAs by anti-EGFR immunonanoparticles
por: Kim, Jung Seok, et al.
Publicado: (2018)

Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy
por: Zhang, Chun-ge, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gphi6hshd6bsrchc71clic8tkv