Cargando…

Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8(mnd) mice

BACKGROUND: CLN8-Batten disease (CLN8 disease) is a rare neurodegenerative disorder characterized phenotypically by progressive deterioration of motor and cognitive abilities, visual symptoms, epileptic seizures, and premature death. Mutations in CLN8 results in characteristic Batten disease symptom...

Descripción completa

Detalles Bibliográficos
Autores principales: Holmes, Andrew D., White, Katherine A., Pratt, Melissa A., Johnson, Tyler B., Likhite, Shibi, Meyer, Kathrin, Weimer, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652919/
https://www.ncbi.nlm.nih.gov/pubmed/36369162
http://dx.doi.org/10.1186/s13023-022-02564-7