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Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8(mnd) mice

BACKGROUND: CLN8-Batten disease (CLN8 disease) is a rare neurodegenerative disorder characterized phenotypically by progressive deterioration of motor and cognitive abilities, visual symptoms, epileptic seizures, and premature death. Mutations in CLN8 results in characteristic Batten disease symptom...

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Detalles Bibliográficos
Autores principales:	Holmes, Andrew D., White, Katherine A., Pratt, Melissa A., Johnson, Tyler B., Likhite, Shibi, Meyer, Kathrin, Weimer, Jill M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652919/ https://www.ncbi.nlm.nih.gov/pubmed/36369162 http://dx.doi.org/10.1186/s13023-022-02564-7

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