Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors

High-grade serous ovarian cancer (HGSOC) is an aggressive disease that typically develops drug resistance, thus novel biomarker-driven strategies are required. Targeted therapy focuses on synthetic lethality—pioneered by PARP inhibition of BRCA1/2-mutant disease. Subsequently, targeting the DNA repl...

Descripción completa

Detalles Bibliográficos
Autores principales: Golder, Anya, Nelson, Louisa, Tighe, Anthony, Barnes, Bethany, Coulson-Gilmer, Camilla, Morgan, Robert D, McGrail, Joanne C, Taylor, Stephen S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653014/
https://www.ncbi.nlm.nih.gov/pubmed/36381271
http://dx.doi.org/10.1093/narcan/zcac036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653014/
https://www.ncbi.nlm.nih.gov/pubmed/36381271
http://dx.doi.org/10.1093/narcan/zcac036

Ejemplares similares