Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice with Methotrexate-Induced Hepatoxicity

PURPOSE: We designed this study to investigate the potential correlations between gut microbiota compositions and hepatic metabolomic disorders in mice with methotrexate (MTX)-induced hepatoxicity. METHODS: We used MTX to induce hepatoxicity in healthy Kunming mice, and we determined plasma ALT and...

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Detalles Bibliográficos
Autores principales: Wang, Changshui, Zhao, Shuzhen, Xu, Yuan, Sun, Wenxue, Feng, Yuanyuan, Liang, Deshuai, Guan, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653027/
https://www.ncbi.nlm.nih.gov/pubmed/36388083
http://dx.doi.org/10.2147/DDDT.S381667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653027/
https://www.ncbi.nlm.nih.gov/pubmed/36388083
http://dx.doi.org/10.2147/DDDT.S381667

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