Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer

Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with metastatic progression. Tumor progression can be influenced by metabolism, including antioxidant glutathione (GSH). Glutathione peroxidase 4 (GPX4) is a selenoenzyme that uses GSH as a co-factor to regulate li...

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Detalles Bibliográficos
Autores principales: Sekhar, Konjeti R., Hanna, David N., Cyr, Sriram, Baechle, Jordan J., Kuravi, Sudhakiranmayi, Balusu, Ramesh, Rathmell, Kimryn, Baregamian, Naira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653479/
https://www.ncbi.nlm.nih.gov/pubmed/36371529
http://dx.doi.org/10.1038/s41598-022-23906-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653479/
https://www.ncbi.nlm.nih.gov/pubmed/36371529
http://dx.doi.org/10.1038/s41598-022-23906-2

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