Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to Cryptococcus spp.

Chimeric antigen receptors (CARs) redirect T cells to recognize a specific target. CAR components play a pivotal role in antigen specificity, structure stability, expression on cell surface, and induction of cellular activation, which together determine the success of CAR T-cell therapy. CAR product...

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Detalles Bibliográficos
Autores principales: dos Santos, Matheus Henrique, Machado, Michele Procópio, Kumaresan, Pappanaicken R., da Silva, Thiago Aparecido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653562/
https://www.ncbi.nlm.nih.gov/pubmed/36359781
http://dx.doi.org/10.3390/cells11213386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653562/
https://www.ncbi.nlm.nih.gov/pubmed/36359781
http://dx.doi.org/10.3390/cells11213386

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