Cargando…

Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to Cryptococcus spp.

Chimeric antigen receptors (CARs) redirect T cells to recognize a specific target. CAR components play a pivotal role in antigen specificity, structure stability, expression on cell surface, and induction of cellular activation, which together determine the success of CAR T-cell therapy. CAR product...

Descripción completa

Detalles Bibliográficos
Autores principales:	dos Santos, Matheus Henrique, Machado, Michele Procópio, Kumaresan, Pappanaicken R., da Silva, Thiago Aparecido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653562/ https://www.ncbi.nlm.nih.gov/pubmed/36359781 http://dx.doi.org/10.3390/cells11213386

Ejemplares similares

Titan Cells and Yeast Forms of Cryptococcus neoformans and Cryptococcus gattii Are Recognized by GXMR-CAR
por: dos Santos, Matheus Henrique, et al.
Publicado: (2021)

Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
por: Fujiwara, Kento, et al.
Publicado: (2020)

Transmembrane signal transduction by cofactor transport
por: Kocsis, Istvan, et al.
Publicado: (2021)

Methods of Controlling Invasive Fungal Infections Using CD8(+) T Cells
por: Kumaresan, Pappanaicken R., et al.
Publicado: (2018)

Structure of the Signal Transduction Domain in Second-Generation CAR Regulates the Input Efficiency of CAR Signals
por: Fujiwara, Kento, et al.
Publicado: (2021)

Phototactic and Chemotactic Signal Transduction by Transmembrane Receptors and Transducers in Microorganisms
por: Suzuki, Daisuke, et al.
Publicado: (2010)

Artificial transmembrane signal transduction mediated by dynamic covalent chemistry
por: Bravin, Carlo, et al.
Publicado: (2021)

Controlled dimerization of artificial membrane receptors for transmembrane signal transduction
por: Chen, Hui, et al.
Publicado: (2021)

Transmembrane signaling: an ion-flux-independent model for signal transduction by complexed Fc receptors
Publicado: (1984)

Engineering transmembrane signal transduction in synthetic membranes using two-component systems
por: Peruzzi, Justin A., et al.
Publicado: (2023)

Essential autoproteolysis of bacterial anti-σ factor RsgI for transmembrane signal transduction
por: Chen, Chao, et al.
Publicado: (2023)

Transmembrane Signal Transduction in Oocyte Maturation and Fertilization: Focusing on Xenopus laevis as a Model Animal
por: Sato, Ken-ichi
Publicado: (2014)

Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors
por: Culhane, Kelly J., et al.
Publicado: (2015)

Light-controlled artificial transmembrane signal transduction for ‘ON/OFF’-switchable transphosphorylation of an RNA model substrate
por: Hou, Jinxing, et al.
Publicado: (2023)

Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct
por: Zenere, Giorgio, et al.
Publicado: (2023)

Altering the threshold of an excitable signal transduction network changes cell migratory modes
por: Miao, Yuchuan, et al.
Publicado: (2017)

The Effects of Chimeric Antigen Receptor (CAR) Hinge Domain Post-Translational Modifications on CAR-T Cell Activity
por: Hirobe, Sachiko, et al.
Publicado: (2022)

Signal transduction
por: Gomperts, B. D.
Publicado: (2002)

Signal transduction and signaling networks
por: Ikeda, Fumiyo, et al.
Publicado: (2013)

Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans
por: Singh, Arpita, et al.
Publicado: (2015)

Integrin signal transduction
por: Leslie, Mitch
Publicado: (2006)

Signal transduction in T lymphocytes
por: Cantrell, D
Publicado: (2005)

Artificial Signal Transduction
por: Bekus, Robert, et al.
Publicado: (2020)

Mitochondrial signal transduction
por: Picard, Martin, et al.
Publicado: (2022)

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations
por: Lemmin, Thomas, et al.
Publicado: (2013)

Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival In Vivo With Low Cytokines Release
por: Zhang, Ang, et al.
Publicado: (2021)

Biophysical Aspects of Transmembrane Signaling
por: Damjanovich, Sandor
Publicado: (2005)

The IgG4 hinge with CD28 transmembrane domain improves V(H)H-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer
por: Li, Nan, et al.
Publicado: (2023)

Mechanisms of Cellular Signal Transduction
por: Li, Shawn
Publicado: (2005)

Signal transduction: evolution of an idea.
por: Rodbell, M
Publicado: (1995)

Cancer, oncogenes and signal transduction
por: McManus, Edward J, et al.
Publicado: (2004)

Self-organization of signal transduction
por: Scheler, Gabriele
Publicado: (2013)

Macropinosomes as units of signal transduction
por: Swanson, Joel A., et al.
Publicado: (2019)

Diacylglycerol Kinases in Signal Transduction
por: Centonze, Sara, et al.
Publicado: (2022)

A novel CD34-derived hinge for rapid and efficient detection and enrichment of CAR T cells
por: Bister, Arthur, et al.
Publicado: (2021)

Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo
por: Bister, A., et al.
Publicado: (2022)

Role of Adenosine and Purinergic Receptors in Myocardial Infarction: Focus on Different Signal Transduction Pathways
por: Procopio, Maria Cristina, et al.
Publicado: (2021)

Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor
por: He, Xinheng, et al.
Publicado: (2022)

Segregation of Ca(2+) signaling in olfactory signal transduction
por: Takeuchi, Hiroko, et al.
Publicado: (2023)

Threshold signals
por: Uhlenbeck, George Eugene, et al.
Publicado: (1950)

Cannot write session to /tmp/vufind_sessions/sess_spa8qp06cfl14d0v2fjko5enr0