Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation

Methotrexate (MTX) is a potent anti-cancer drug, commonly associated with nephrotoxicity via the induction of oxidative stress and apoptosis with alteration of renal water channel proteins, namely aquaporins (AQPs). Omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) have shown cytoprotective e...

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Detalles Bibliográficos
Autores principales: El-Agawy, Mosaab Salah El-din, Badawy, Alaa Mohamed Mohamed, Rabei, Mohammed R., Elshaer, Mohamed Mahmoud Abdelraheem, El Nashar, Eman Mohamad, Alghamdi, Mansour A., Alshehri, Mohammed A., Elsayed, Hassan Reda Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653681/
https://www.ncbi.nlm.nih.gov/pubmed/36361584
http://dx.doi.org/10.3390/ijms232112794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653681/
https://www.ncbi.nlm.nih.gov/pubmed/36361584
http://dx.doi.org/10.3390/ijms232112794

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