FIP200 Methylation by SETD2 Prevents Trim21-Induced Degradation and Preserves Autophagy Initiation

FIP200, also known as RB1CC1, is a protein that assembles the autophagy initiation complex. Its post-translational modifications and degradation mechanisms are unclear. Upon autophagy activation, we find that FIP200 is methylated at lysine1133 (K1133) by methyltransferase SETD2. We identify the E3 l...

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Detalles Bibliográficos
Autores principales: Dai, Yuan, Luo, Weijia, Li, Wenjiao, Chen, Zhishi, Wang, Xinjie, Chang, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653720/
https://www.ncbi.nlm.nih.gov/pubmed/36359729
http://dx.doi.org/10.3390/cells11213333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653720/
https://www.ncbi.nlm.nih.gov/pubmed/36359729
http://dx.doi.org/10.3390/cells11213333

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