Quercetin and Isorhamnetin Reduce Benzo[a]pyrene-Induced Genotoxicity by Inducing RAD51 Expression through Downregulation of miR−34a

Benzo[a]pyrene (B[a]P) is metabolized in the liver into highly reactive mutagenic and genotoxic metabolites, which induce carcinogenesis. The mutagenic factors, including B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) and reactive oxygen species, generated during B[a]P metabolism can cause DNA damage, su...

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Detalles Bibliográficos
Autores principales: Kim, Min, Jee, Seung-Cheol, Shin, Min-Kyoung, Han, Dong-Hee, Bu, Kyung-Bin, Lee, Seung-Cheol, Jang, Bo-Young, Sung, Jung-Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653982/
https://www.ncbi.nlm.nih.gov/pubmed/36361910
http://dx.doi.org/10.3390/ijms232113125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653982/
https://www.ncbi.nlm.nih.gov/pubmed/36361910
http://dx.doi.org/10.3390/ijms232113125

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