Cargando…

Quercetin and Isorhamnetin Reduce Benzo[a]pyrene-Induced Genotoxicity by Inducing RAD51 Expression through Downregulation of miR−34a

Benzo[a]pyrene (B[a]P) is metabolized in the liver into highly reactive mutagenic and genotoxic metabolites, which induce carcinogenesis. The mutagenic factors, including B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) and reactive oxygen species, generated during B[a]P metabolism can cause DNA damage, su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Min, Jee, Seung-Cheol, Shin, Min-Kyoung, Han, Dong-Hee, Bu, Kyung-Bin, Lee, Seung-Cheol, Jang, Bo-Young, Sung, Jung-Suk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653982/ https://www.ncbi.nlm.nih.gov/pubmed/36361910 http://dx.doi.org/10.3390/ijms232113125

Ejemplares similares

Quercetin and Isorhamnetin Attenuate Benzo[a]pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways
por: Kim, Min, et al.
Publicado: (2021)

Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells
por: Lee, Seung-Cheol, et al.
Publicado: (2021)

Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Solar simulated light exposure alters metabolization and genotoxicity induced by benzo[a]pyrene in human skin
por: von Koschembahr, Anne, et al.
Publicado: (2018)

Metabolically Competent Human Skin Models: Activation and Genotoxicity of Benzo[a]pyrene
por: Brinkmann, Joep, et al.
Publicado: (2013)

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
por: Dračínská, Helena, et al.
Publicado: (2021)

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
por: Mason, Jennifer M., et al.
Publicado: (2015)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

Mechanisms of Resorcinol Antagonism of Benzo[a]pyrene-Induced Damage to Human Keratinocytes
por: Lee, Seung Eun, et al.
Publicado: (2021)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
por: Wang, Huizeng, et al.
Publicado: (2023)

Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates
por: González-Arceo, Maitane, et al.
Publicado: (2022)

Roles of XRCC2, RAD51B and RAD51D in RAD51-Independent SSA Recombination
por: Serra, Heïdi, et al.
Publicado: (2013)

Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51
por: Wang, Bingliang, et al.
Publicado: (2015)

Isorhamnetin and Quercetin Derivatives as Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations
por: Olennikov, Daniil N., et al.
Publicado: (2017)

Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects
por: Lin, Shanshan, et al.
Publicado: (2018)

Evaluation of benzo[a]pyrene-induced toxicity in the estuarine thornfish Therapon jarbua
por: Sathikumaran, R., et al.
Publicado: (2022)

Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats
por: Kang, Hwan Goo, et al.
Publicado: (2007)

Species and Strain Differences in the Susceptibility of the Cervico-Vaginal Squamous Epithelium to 3,4-Benzo(a)pyrene
por: Thiery, M., et al.
Publicado: (1965)

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor
por: Greenhough, Luke A., et al.
Publicado: (2023)

Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System
por: Tanaka, Yuka, et al.
Publicado: (2020)

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro
por: Sun, Jing, et al.
Publicado: (2013)

The Extreme Variety of Genotoxic Response to Benzo[a]pyrene in Three Different Human Cell Lines from Three Different Organs
por: Genies, Camille, et al.
Publicado: (2013)

Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
por: Abbass, Mustafa, et al.
Publicado: (2021)

Free radicals of benzo(a)pyrene and derivatives.
por: Sullivan, P D
Publicado: (1985)

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
por: Zellweger, Ralph, et al.
Publicado: (2015)

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2
por: Morozumi, Yuichi, et al.
Publicado: (2013)

Antagonizing Effects of Clematis apiifolia DC. Extract against Benzo[a]pyrene-Induced Damage to Human Keratinocytes
por: Lee, Seung Eun, et al.
Publicado: (2019)

Quercetin and its metabolite isorhamnetin promote glucose uptake through different signalling pathways in myotubes
por: Jiang, Hao, et al.
Publicado: (2019)

Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn. fruit extract.
por: Nandi, P., et al.
Publicado: (1997)

Studies on in vitro chrysotile-pleural mesothelial cell interaction: morphological aspects and metabolism of benzo-3,4-pyrene.
por: Jaurand, M C, et al.
Publicado: (1983)

Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene.
por: Lee, Y. S., et al.
Publicado: (1991)

Immunomodulatory Effect of Mangiferin in Experimental Animals with Benzo(a)Pyrene-induced Lung Carcinogenesis
por: Rajendran, Peramaiyan, et al.
Publicado: (2013)

Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring
por: Beal, Marc A., et al.
Publicado: (2019)

Investigation on the Protective Effects of Cranberry Against the DNA Damage Induced by Benzo[a]pyrene
por: Madrigal-Santillán, Eduardo, et al.
Publicado: (2012)

Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor
por: Shiizaki, Kazuhiro, et al.
Publicado: (2017)

Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling
por: Kohno, Risa, et al.
Publicado: (2023)

Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps
por: Maloisel, Laurent, et al.
Publicado: (2023)

Rad51 paralogs Rad55-Rad57 balance the anti-recombinase Srs2 in Rad51 filament formation
por: Liu, Jie, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6iagl3ulkqe2o9vlb8motjgj7j