New Positive TRPC6 Modulator Penetrates Blood–Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice

Synapse loss in the brain of Alzheimer’s disease patients correlates with cognitive dysfunctions. Drugs that limit synaptic loss are promising pharmacological agents. The transient receptor potential cation channel, subfamily C, member 6 (TRPC6) regulates the formation of an excitatory synapse. Posi...

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Detalles Bibliográficos
Autores principales: Zernov, Nikita, Veselovsky, Alexander V., Poroikov, Vladimir V., Melentieva, Daria, Bolshakova, Anastasia, Popugaeva, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653995/
https://www.ncbi.nlm.nih.gov/pubmed/36362339
http://dx.doi.org/10.3390/ijms232113552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653995/
https://www.ncbi.nlm.nih.gov/pubmed/36362339
http://dx.doi.org/10.3390/ijms232113552

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