Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes

Steady-state lymphatic endothelial cells (LECs) can induce peripheral tolerance by presenting endogenous antigens on MHC class I (MHC-I) molecules. Recent evidence suggests that lymph node LECs can cross-present tumor antigens on MHC-I to suppress tumor-specific CD8+ T cells. Whether LECs can act as...

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Detalles Bibliográficos
Autores principales: Li, Claire Y., Park, Hyeung Ju, Shin, Jinyeon, Baik, Jung Eun, Mehrara, Babak J., Kataru, Raghu P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654328/
https://www.ncbi.nlm.nih.gov/pubmed/36362253
http://dx.doi.org/10.3390/ijms232113470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654328/
https://www.ncbi.nlm.nih.gov/pubmed/36362253
http://dx.doi.org/10.3390/ijms232113470

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