Next-Generation Antisense Oligonucleotide of TGF-β2 Enhances T Cell-Mediated Anticancer Efficacy of Anti-PD-1 Therapy in a Humanized Mouse Model of Immune-Excluded Melanoma

SIMPLE SUMMARY: Upregulation of transforming growth factor-beta (TGF-β) signaling in melanoma contributes to the formation of immune-suppressive tumoral environments and is associated with poor response to immunotherapeutics, including anti-programmed death-1 (PD-1) therapy. Our study aimed to inves...

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Detalles Bibliográficos
Autores principales: Lee, Hong Kyu, Kim, Cho-Won, Ahn, Dohee, Go, Ryeo-Eun, Choi, Youngdong, Choi, Kyung-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654371/
https://www.ncbi.nlm.nih.gov/pubmed/36358638
http://dx.doi.org/10.3390/cancers14215220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654371/
https://www.ncbi.nlm.nih.gov/pubmed/36358638
http://dx.doi.org/10.3390/cancers14215220

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