Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B

Human topoisomerase 1B regulates the topological state of supercoiled DNA enabling all fundamental cell processes. This enzyme, which is the unique molecular target of the natural anticancer compound camptothecin, acts by nicking one DNA strand and forming a transient protein–DNA covalent complex. T...

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Detalles Bibliográficos
Autores principales: Ottaviani, Alessio, Iacovelli, Federico, Welsch, Joshua, Morozzo della Rocca, Blasco, Desideri, Alessandro, Falconi, Mattia, Calcul, Laurent, Baker, Bill J., Fiorani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654473/
https://www.ncbi.nlm.nih.gov/pubmed/36359884
http://dx.doi.org/10.3390/cells11213486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654473/
https://www.ncbi.nlm.nih.gov/pubmed/36359884
http://dx.doi.org/10.3390/cells11213486

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