Cargando…

Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B

Human topoisomerase 1B regulates the topological state of supercoiled DNA enabling all fundamental cell processes. This enzyme, which is the unique molecular target of the natural anticancer compound camptothecin, acts by nicking one DNA strand and forming a transient protein–DNA covalent complex. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ottaviani, Alessio, Iacovelli, Federico, Welsch, Joshua, Morozzo della Rocca, Blasco, Desideri, Alessandro, Falconi, Mattia, Calcul, Laurent, Baker, Bill J., Fiorani, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654473/ https://www.ncbi.nlm.nih.gov/pubmed/36359884 http://dx.doi.org/10.3390/cells11213486

Ejemplares similares

Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
por: Tesauro, Cinzia, et al.
Publicado: (2013)

In Vitro and In Silico Characterization of an Antimalarial Compound with Antitumor Activity Targeting Human DNA Topoisomerase IB
por: Soren, Bini Chhetri, et al.
Publicado: (2021)

Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB
por: Ottaviani, Alessio, et al.
Publicado: (2021)

Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant
por: Arnò, Barbara, et al.
Publicado: (2013)

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
por: Ottaviani, Alessio, et al.
Publicado: (2022)

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant
por: Fiorani, Paola, et al.
Publicado: (2006)

Topoisomerase IB: a relaxing enzyme for stressed DNA
por: Soren, Bini Chhetri, et al.
Publicado: (2020)

Engineering a responsive DNA triple helix into an octahedral DNA nanostructure for a reversible opening/closing switching mechanism: a computational and experimental integrated study
por: Ottaviani, Alessio, et al.
Publicado: (2018)

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
por: D'Annessa, Ilda, et al.
Publicado: (2012)

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers
por: Tesauro, Cinzia, et al.
Publicado: (2014)

Luteolin-7-O-β-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes
por: Palombo, Ramona, et al.
Publicado: (2019)

Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study
por: Coletta, Andrea, et al.
Publicado: (2013)

Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin
por: Zhang, Lan, et al.
Publicado: (2013)

New Topoisomerase I mutations are associated with resistance to camptothecin
por: Gongora, Céline, et al.
Publicado: (2011)

Differential induction of Leishmania donovani bi-subunit topoisomerase I–DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I
por: Das, Benu Brata, et al.
Publicado: (2006)

Geometrically Induced Selectivity and Unidirectional Electroosmosis in Uncharged Nanopores
por: Di Muccio, Giovanni, et al.
Publicado: (2022)

The open state of human topoisomerase I as probed by molecular dynamics simulation
por: Chillemi, Giovanni, et al.
Publicado: (2007)

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer
por: Lee, Yu-Chieh, et al.
Publicado: (2015)

Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure
por: Lacombe, Otto Kischlat, et al.
Publicado: (2014)

Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins
por: Pommier, Yves, et al.
Publicado: (2018)

Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibition
por: Nishida, Masahiro, et al.
Publicado: (2022)

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability
por: Fulci, Chiara, et al.
Publicado: (2017)

Evaluation of Two Models for Human Topoisomerase I Interaction with dsDNA and Camptothecin Derivatives
por: Laco, Gary S.
Publicado: (2011)

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway
por: Ando, Koji, et al.
Publicado: (2017)

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants
por: Inoue, Naomi, et al.
Publicado: (2021)

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal
por: Frøhlich, Rikke From, et al.
Publicado: (2007)

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study
por: Tesauro, Cinzia, et al.
Publicado: (2019)

CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity
por: Bandyopadhyay, Keya, et al.
Publicado: (2012)

Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study
por: Chillemi, Giovanni, et al.
Publicado: (2005)

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
Publicado: (1996)

Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines
por: ARAKAWA, YASUHIRO, et al.
Publicado: (2013)

Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations
por: Chillemi, Giovanni, et al.
Publicado: (2008)

The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis
por: Czuwara-Ladykowska, Joanna, et al.
Publicado: (2001)

Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells
por: Wolff, David W., et al.
Publicado: (2018)

Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
por: Matsuno, Yusuke, et al.
Publicado: (2018)

In Silico and In Cell Analysis of Openable DNA Nanocages for miRNA Silencing
por: Raniolo, Sofia, et al.
Publicado: (2019)

Semisynthetic Pneumococcal Glycoconjugate Nanovaccine
por: Prasanna, Maruthi, et al.
Publicado: (2023)

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells
por: Sharma, Nilesh K., et al.
Publicado: (2015)

Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
por: Wu, Ying, et al.
Publicado: (2014)

PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin
por: Mouly, Laetitia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_elj8ljrk5mrlvufv7heho1hacr