Antisense Gapmers with LNA-Wings and (S)-5′-C-Aminopropyl-2′-arabinofluoro-nucleosides Could Efficiently Suppress the Expression of KNTC2

Previously reported (S)-5′-C-aminopropyl-2′-arabinofluoro-thymidine (5ara-T) and newly synthesized (S)-5′-C-aminopropyl-2′-arabinofluoro-5-methyl-cytidine (5ara-(Me)C) analogs were incorporated into a series of antisense gapmers containing multiple phosphorothioate (PS) linkages and locked nucleic a...

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Detalles Bibliográficos
Autores principales: Zhou, Yujun, Sakamoto, Shuichi, Ueno, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654562/
https://www.ncbi.nlm.nih.gov/pubmed/36364210
http://dx.doi.org/10.3390/molecules27217384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654562/
https://www.ncbi.nlm.nih.gov/pubmed/36364210
http://dx.doi.org/10.3390/molecules27217384

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