Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein

Hyperphosphorylation and aggregation of the microtubule binding protein tau is a neuropathological hallmark of Alzheimer’s disease/tauopathies. Tau neurotoxicity provokes alterations in brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase B (TRKB)/cAMP-response-element binding protein...

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Detalles Bibliográficos
Autores principales: Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Weng, Zheng-Kui, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654711/
https://www.ncbi.nlm.nih.gov/pubmed/36361524
http://dx.doi.org/10.3390/ijms232112734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654711/
https://www.ncbi.nlm.nih.gov/pubmed/36361524
http://dx.doi.org/10.3390/ijms232112734

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