Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies

In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile (5a-f) and 3,4,7,8-tetrahydro pyrimidine-6-carbonitrile (6a-b and 7a-e). The newly synthesized compounds’ structure w...

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Detalles Bibliográficos
Autores principales: Al-Warhi, Tarfah, Sallam, Al-Aliaa M., Hemeda, Loah R., El Hassab, Mahmoud A., Aljaeed, Nada, Alotaibi, Ohoud J., Doghish, Ahmed S., Noshy, Mina, Eldehna, Wagdy M., Ibrahim, Mona H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655118/
https://www.ncbi.nlm.nih.gov/pubmed/36297374
http://dx.doi.org/10.3390/ph15101262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655118/
https://www.ncbi.nlm.nih.gov/pubmed/36297374
http://dx.doi.org/10.3390/ph15101262

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