Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific inhibitors of PDHC in vivo, we determine biochemical and physiological responses to PDHC dysfunction. Dose dependence of the r...

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Detalles Bibliográficos
Autores principales: Artiukhov, Artem V., Aleshin, Vasily A., Karlina, Irina S., Kazantsev, Alexey V., Sibiryakina, Daria A., Ksenofontov, Alexander L., Lukashev, Nikolay V., Graf, Anastasia V., Bunik, Victoria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655319/
https://www.ncbi.nlm.nih.gov/pubmed/36361974
http://dx.doi.org/10.3390/ijms232113186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655319/
https://www.ncbi.nlm.nih.gov/pubmed/36361974
http://dx.doi.org/10.3390/ijms232113186

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