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Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption

Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We tested whether...

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Autores principales: Valencia, Ana P., Whitson, Jeremy A., Wang, Shari, Nguyen, Leon, den Hartigh, Laura J., Rabinovitch, Peter S., Marcinek, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655368/
https://www.ncbi.nlm.nih.gov/pubmed/36364920
http://dx.doi.org/10.3390/nu14214645
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author Valencia, Ana P.
Whitson, Jeremy A.
Wang, Shari
Nguyen, Leon
den Hartigh, Laura J.
Rabinovitch, Peter S.
Marcinek, David J.
author_facet Valencia, Ana P.
Whitson, Jeremy A.
Wang, Shari
Nguyen, Leon
den Hartigh, Laura J.
Rabinovitch, Peter S.
Marcinek, David J.
author_sort Valencia, Ana P.
collection PubMed
description Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We tested whether HS diet (60%kcal sucrose) would accelerate muscle dysfunction in 24-month-old male CB6F1 mice. By week 1 on HS diet, mice developed significant cardiac hypertrophy compared to age-matched chow-fed controls. The increased weight of the heart persisted throughout the 4-week treatment, while body weight and strength declined more rapidly than controls. We then tested whether HS diet could worsen cardiac dysfunction in old mice and if the mitochondrial-targeted drug, elamipretide (ELAM), could prevent the diet-induced effect. Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week. As demonstrated in the previous experiment, old mice had age-related cardiac hypertrophy that worsened after one week on HS and was prevented by ELAM treatment, while the HS diet had no detectable effect on hypertrophy in the young mice. As expected, mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM. Our findings highlight the vulnerability of the aged heart to HS diet that can be prevented by systemic targeting of the mitochondria with ELAM.
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spelling pubmed-96553682022-11-15 Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption Valencia, Ana P. Whitson, Jeremy A. Wang, Shari Nguyen, Leon den Hartigh, Laura J. Rabinovitch, Peter S. Marcinek, David J. Nutrients Article Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We tested whether HS diet (60%kcal sucrose) would accelerate muscle dysfunction in 24-month-old male CB6F1 mice. By week 1 on HS diet, mice developed significant cardiac hypertrophy compared to age-matched chow-fed controls. The increased weight of the heart persisted throughout the 4-week treatment, while body weight and strength declined more rapidly than controls. We then tested whether HS diet could worsen cardiac dysfunction in old mice and if the mitochondrial-targeted drug, elamipretide (ELAM), could prevent the diet-induced effect. Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week. As demonstrated in the previous experiment, old mice had age-related cardiac hypertrophy that worsened after one week on HS and was prevented by ELAM treatment, while the HS diet had no detectable effect on hypertrophy in the young mice. As expected, mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM. Our findings highlight the vulnerability of the aged heart to HS diet that can be prevented by systemic targeting of the mitochondria with ELAM. MDPI 2022-11-03 /pmc/articles/PMC9655368/ /pubmed/36364920 http://dx.doi.org/10.3390/nu14214645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valencia, Ana P.
Whitson, Jeremy A.
Wang, Shari
Nguyen, Leon
den Hartigh, Laura J.
Rabinovitch, Peter S.
Marcinek, David J.
Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title_full Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title_fullStr Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title_full_unstemmed Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title_short Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption
title_sort aging increases susceptibility to develop cardiac hypertrophy following high sugar consumption
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655368/
https://www.ncbi.nlm.nih.gov/pubmed/36364920
http://dx.doi.org/10.3390/nu14214645
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