Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy

Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is observed in many human cancers. PKM2 plays a vital role in metabolic reprogramming, transcription and cell cycle progression and thus is delibera...

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Detalles Bibliográficos
Autores principales: Adnan, Mohd, Shamsi, Anas, Elasbali, Abdelbaset Mohamed, Siddiqui, Arif Jamal, Patel, Mitesh, Alshammari, Nawaf, Alharethi, Salem Hussain, Alhassan, Hassan H., Bardakci, Fevzi, Hassan, Md. Imtaiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655700/
https://www.ncbi.nlm.nih.gov/pubmed/36361954
http://dx.doi.org/10.3390/ijms232113172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655700/
https://www.ncbi.nlm.nih.gov/pubmed/36361954
http://dx.doi.org/10.3390/ijms232113172

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