The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells

SIMPLE SUMMARY: The histone methyltransferase SET domain-containing protein 8 (SETD8) methylates histone H4 lysine 20 and non-histone proteins such as p53. Our aim was to determine the involvement of SETD8 in endometrial cancer and its therapeutic potential and identify the downstream genes regulate...

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Detalles Bibliográficos
Autores principales: Kukita, Asako, Sone, Kenbun, Kaneko, Syuzo, Kawakami, Eiryo, Oki, Shinya, Kojima, Machiko, Wada, Miku, Toyohara, Yusuke, Takahashi, Yu, Inoue, Futaba, Tanimoto, Saki, Taguchi, Ayumi, Fukuda, Tomohiko, Miyamoto, Yuichiro, Tanikawa, Michihiro, Mori-Uchino, Mayuyo, Tsuruga, Tetsushi, Iriyama, Takayuki, Matsumoto, Yoko, Nagasaka, Kazunori, Wada-Hiraike, Osamu, Oda, Katsutoshi, Hamamoto, Ryuji, Osuga, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655767/
https://www.ncbi.nlm.nih.gov/pubmed/36358786
http://dx.doi.org/10.3390/cancers14215367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655767/
https://www.ncbi.nlm.nih.gov/pubmed/36358786
http://dx.doi.org/10.3390/cancers14215367

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