Efficient Synthesis of Key Chiral Intermediate in Painkillers (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine by Bienzyme Cascade System with R-ω-Transaminase and Alcohol Dehydrogenase Functions

(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanamine, a key chiral intermediate of selective tetrodotoxin-sensitive blockers, was efficiently synthesized by a bienzyme cascade system formed by with R-ω-transaminase (ATA117) and an alcohol dehydrogenase (ADH) co-expression system. Herein, we report that...

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Detalles Bibliográficos
Autores principales: Lu, Yuan, Wang, Jinmei, Xu, Haobo, Zhang, Chuyue, Cheng, Pengpeng, Du, Lihua, Tang, Lan, Li, Jinghua, Ou, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655816/
https://www.ncbi.nlm.nih.gov/pubmed/36364166
http://dx.doi.org/10.3390/molecules27217331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9655816/
https://www.ncbi.nlm.nih.gov/pubmed/36364166
http://dx.doi.org/10.3390/molecules27217331

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