In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part I

Translation of the synergy between the Siremadlin (MDM2 inhibitor) and Trametinib (MEK inhibitor) combination observed in vitro into in vivo synergistic efficacy in melanoma requires estimation of the interaction between these molecules at the pharmacokinetic (PK) and pharmacodynamic (PD) levels. Th...

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Detalles Bibliográficos
Autores principales: Witkowski, Jakub, Polak, Sebastian, Rogulski, Zbigniew, Pawelec, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656205/
https://www.ncbi.nlm.nih.gov/pubmed/36361773
http://dx.doi.org/10.3390/ijms232112984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656205/
https://www.ncbi.nlm.nih.gov/pubmed/36361773
http://dx.doi.org/10.3390/ijms232112984

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