Cargando…

From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke

Cigarette smoking causes hypomethylation of the gene Aryl Hydrocarbon Receptor Repressor (AHRR), which regulates detoxification and oxidative stress-responses. We investigated whether AHRR DNA methylation is related to chronic obstructive pulmonary disease (COPD) and studied its function in airway e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Qing, Nwozor, Kingsley Okechukwu, van den Berge, Maarten, Slebos, Dirk-Jan, Faiz, Alen, Jonker, Marnix R., Boezen, H. Marike, Heijink, Irene H., de Vries, Maaike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656229/ https://www.ncbi.nlm.nih.gov/pubmed/36359818 http://dx.doi.org/10.3390/cells11213423

Ejemplares similares

A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract
por: Chen, Qing, et al.
Publicado: (2021)

No association between DNA methylation and COPD in never and current smokers
por: de Vries, Maaike, et al.
Publicado: (2018)

Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release
por: Faiz, Alen, et al.
Publicado: (2018)

Acute cigarette smoke‐induced eQTL affects formyl peptide receptor expression and lung function
por: Pouwels, Simon D., et al.
Publicado: (2020)

The relation between age and airway epithelial barrier function
por: de Vries, M., et al.
Publicado: (2022)

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
por: Woldhuis, Roy R, et al.
Publicado: (2021)

Advanced glycation endproducts and their receptor in different body compartments in COPD
por: Hoonhorst, Susan J. M., et al.
Publicado: (2016)

Connecting GWAS Susceptibility Genes in COPD: Do We Need to Consider TGF-β2?
por: Chen, Qing, et al.
Publicado: (2021)

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach
por: Conickx, Griet, et al.
Publicado: (2017)

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
por: Hoonhorst, Susan JM, et al.
Publicado: (2014)

Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation
por: Philibert, Robert, et al.
Publicado: (2016)

Poor Prognosis of Gastric Adenocarcinoma with Decreased Expression of AHRR
por: Li, Yuan-fang, et al.
Publicado: (2012)

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
por: van Nijnatten, Jos, et al.
Publicado: (2022)

The contribution of reticular basement membrane proteins to basal airway epithelial attachment, spreading and barrier formation: implications for airway remodeling in asthma
por: Hsieh, Aileen, et al.
Publicado: (2023)

Lower Corticosteroid Skin Blanching Response Is Associated with Severe COPD
por: Hoonhorst, Susan J. M., et al.
Publicado: (2014)

Sputum microbiome profiling in COPD: beyond singular pathogen detection
por: Ditz, Benedikt, et al.
Publicado: (2020)

A bronchial gene signature specific for severe COPD that is retained in the nose
por: van Nijnatten, Jos, et al.
Publicado: (2023)

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression
por: Boudewijn, Ilse M., et al.
Publicado: (2017)

Reply to Biswas: Acute and Chronic Effects of Cigarette Smoking on sRAGE
por: Pouwels, Simon D., et al.
Publicado: (2019)

Hypomethylation of AHRR (cg05575921) Is Related to Smoking Status in the Mexican Mestizo Population
por: Bravo-Gutiérrez, Omar Andrés, et al.
Publicado: (2021)

AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality
por: Bojesen, Stig E, et al.
Publicado: (2017)

AhRR methylation contributes to disease progression in urothelial bladder cancer
por: El-Haddad, Nataly W., et al.
Publicado: (2022)

Single-nucleotide polymorphism rs2070600 regulates AGER splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products
por: Faiz, Alen, et al.
Publicado: (2021)

Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD
por: Heijink, Irene H, et al.
Publicado: (2011)

Transcriptome-based Signatures: The Future Biomarkers in Obstructive Pulmonary Diseases Such as Asthma and Chronic Obstructive Pulmonary Disease?
por: van den Berge, Maarten, et al.
Publicado: (2021)

From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function
por: de Vries, Maaike, et al.
Publicado: (2018)

AHRR (cg05575921) methylation extent of leukocyte DNA and lung cancer survival
por: Kemp Jacobsen, Katja, et al.
Publicado: (2019)

Expression analysis of aryl hydrocarbon receptor repressor (AHRR) gene in gallbladder cancer
por: Kumar, Puneet, et al.
Publicado: (2020)

AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children
por: Vidal, Adriana C., et al.
Publicado: (2023)

Nicotinic Acetylcholine Receptor Variants Are Related to Smoking Habits, but Not Directly to COPD
por: Budulac, Simona E., et al.
Publicado: (2012)

Free circulating mircoRNAs support the diagnosis of invasive aspergillosis in patients with hematologic malignancies and neutropenia
por: Tolnai, Emese, et al.
Publicado: (2020)

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression
por: Nedeljkovic, Ivana, et al.
Publicado: (2018)

Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins
por: Porosk, Ly, et al.
Publicado: (2021)

Decorin and TGF-β(1 )polymorphisms and development of COPD in a general population
por: van Diemen, Cleo C, et al.
Publicado: (2006)

Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease
por: Weidner, Julie, et al.
Publicado: (2017)

Longitudinal Effects of 1-Year Smoking Cessation on Human Bronchial Epithelial Transcriptome
por: Rathnayake, Senani N.H., et al.
Publicado: (2023)

Gene network approach reveals co-expression patterns in nasal and bronchial epithelium
por: Imkamp, Kai, et al.
Publicado: (2019)

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
por: van den Berge, Maarten, et al.
Publicado: (2014)

AHRR methylation in heavy smokers: associations with smoking, lung cancer risk, and lung cancer mortality
por: Grieshober, Laurie, et al.
Publicado: (2020)

Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
por: Kruk, Dennis, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_46rqc7qisuof3h7d3f0rt08ft6