Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling

Hypothyroidism has been shown to reduce infarct size in rats, but the underlying mechanisms are unclear. We used isolated pressure-constant perfused hearts of control, hypothyroid and hyperthyroid mice and measured infarct size, functional parameters and phosphorylation of key molecules in cardiopro...

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Detalles Bibliográficos
Autores principales: Pape, Janina, Kerp, Helena, Lieder, Helmut R., Geist, Daniela, Hönes, Georg Sebastian, Moeller, Lars C., Kleinbongard, Petra, Führer, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656281/
https://www.ncbi.nlm.nih.gov/pubmed/36362133
http://dx.doi.org/10.3390/ijms232113340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656281/
https://www.ncbi.nlm.nih.gov/pubmed/36362133
http://dx.doi.org/10.3390/ijms232113340

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