DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex

SIMPLE SUMMARY: The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating DNA double-strand break repair and activating several downstream proteins. These proteins have been studied for their individual roles in inherited cancers and are included on several genetic testing panels. However, la...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarthy-Leo, Claire, Darwiche, Fatima, Tainsky, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656488/
https://www.ncbi.nlm.nih.gov/pubmed/36358700
http://dx.doi.org/10.3390/cancers14215278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656488/
https://www.ncbi.nlm.nih.gov/pubmed/36358700
http://dx.doi.org/10.3390/cancers14215278

Ejemplares similares