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DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex

SIMPLE SUMMARY: The MRN Complex (MRE11-RAD50-NBS1) is responsible for initiating DNA double-strand break repair and activating several downstream proteins. These proteins have been studied for their individual roles in inherited cancers and are included on several genetic testing panels. However, la...

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Detalles Bibliográficos
Autores principales:	McCarthy-Leo, Claire, Darwiche, Fatima, Tainsky, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656488/ https://www.ncbi.nlm.nih.gov/pubmed/36358700 http://dx.doi.org/10.3390/cancers14215278

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