Diacidic Motifs in the Carboxyl Terminus Are Required for ER Exit and Translocation to the Plasma Membrane of NKCC2

Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome (BS1), a life-threatening kidney disease. We have previously demonstrated that the BS1 variant Y998X, which deprives NKCC2 from its highly conserved dileucine-like motifs, compromises co-transporter surface deliver...

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Detalles Bibliográficos
Autores principales: Bakhos-Douaihy, Dalal, Seaayfan, Elie, Frachon, Nadia, Demaretz, Sylvie, Kömhoff, Martin, Laghmani, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656672/
https://www.ncbi.nlm.nih.gov/pubmed/36361553
http://dx.doi.org/10.3390/ijms232112761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656672/
https://www.ncbi.nlm.nih.gov/pubmed/36361553
http://dx.doi.org/10.3390/ijms232112761

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