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Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compou...

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Detalles Bibliográficos
Autores principales: Mukusheva, Gulim K., Zhasymbekova, Aigerym R., Zhumagalieva, Zharkyn Zh., Seidakhmetova, Roza B., Nurkenov, Oralgazy A., Akishina, Ekaterina A., Petkevich, Sergey K., Dikusar, Evgenij A., Potkin, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656753/
https://www.ncbi.nlm.nih.gov/pubmed/36364219
http://dx.doi.org/10.3390/molecules27217387
Descripción
Sumario:A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity, reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties.