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Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments

A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compou...

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Autores principales: Mukusheva, Gulim K., Zhasymbekova, Aigerym R., Zhumagalieva, Zharkyn Zh., Seidakhmetova, Roza B., Nurkenov, Oralgazy A., Akishina, Ekaterina A., Petkevich, Sergey K., Dikusar, Evgenij A., Potkin, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656753/
https://www.ncbi.nlm.nih.gov/pubmed/36364219
http://dx.doi.org/10.3390/molecules27217387
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author Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Zhumagalieva, Zharkyn Zh.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
author_facet Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Zhumagalieva, Zharkyn Zh.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
author_sort Mukusheva, Gulim K.
collection PubMed
description A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity, reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties.
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spelling pubmed-96567532022-11-15 Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments Mukusheva, Gulim K. Zhasymbekova, Aigerym R. Zhumagalieva, Zharkyn Zh. Seidakhmetova, Roza B. Nurkenov, Oralgazy A. Akishina, Ekaterina A. Petkevich, Sergey K. Dikusar, Evgenij A. Potkin, Vladimir I. Molecules Article A series of N-acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the adamantane derivatives showed the greatest antiviral effect. It was found that the majority of anabasine derivatives showed significant analgesic activity, reducing the pain response of animals to the irritating effect of acetic acid. The presence of a high level of antimicrobial and antiviral activity in newly synthesized compounds makes it possible to consider them promising for further study of their pharmacological properties. MDPI 2022-10-31 /pmc/articles/PMC9656753/ /pubmed/36364219 http://dx.doi.org/10.3390/molecules27217387 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Zhumagalieva, Zharkyn Zh.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title_full Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title_fullStr Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title_full_unstemmed Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title_short Synthesis and Biological Activity of N-acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments
title_sort synthesis and biological activity of n-acyl anabasine and cytisine derivatives with adamantane, pyridine and 1,2-azole fragments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656753/
https://www.ncbi.nlm.nih.gov/pubmed/36364219
http://dx.doi.org/10.3390/molecules27217387
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