Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the BRCA1 gene causing inferior survival of breast cancer patients. Most studies have focused on...

Descripción completa

Detalles Bibliográficos
Autores principales: Classen, Sandra, Rahlf, Elena, Jungwirth, Johannes, Albers, Nina, Hebestreit, Luca Philipp, Zielinski, Alexandra, Poole, Lena, Groth, Marco, Koch, Philipp, Liehr, Thomas, Kankel, Stefanie, Cordes, Nils, Petersen, Cordula, Rothkamm, Kai, Pospiech, Helmut, Borgmann, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656774/
https://www.ncbi.nlm.nih.gov/pubmed/36362151
http://dx.doi.org/10.3390/ijms232113363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656774/
https://www.ncbi.nlm.nih.gov/pubmed/36362151
http://dx.doi.org/10.3390/ijms232113363

Ejemplares similares