Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection

The interest in therapeutic monoclonal antibodies (mAbs) has continuously growing in several diseases. However, their pharmacokinetics (PK) is complex due to their target-mediated drug disposition (TMDD) profiles which can induce a non-linear PK. This point is particularly challenging during the pre...

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Detalles Bibliográficos
Autores principales: Pasquiers, Blaise, Benamara, Salih, Felices, Mathieu, Nguyen, Laurent, Declèves, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657028/
https://www.ncbi.nlm.nih.gov/pubmed/36361546
http://dx.doi.org/10.3390/ijms232112754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657028/
https://www.ncbi.nlm.nih.gov/pubmed/36361546
http://dx.doi.org/10.3390/ijms232112754

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