Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase

The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12 and 0.30 ± 0.32 M, respectively), the inhibit...

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Detalles Bibliográficos
Autores principales: Khan, Shoaib, Iqbal, Shahid, Taha, Muhammad, Rahim, Fazal, Shah, Mazloom, Ullah, Hayat, Bahadur, Ali, Alrbyawi, Hamad, Dera, Ayed A., Alahmdi, Mohammed Issa, Pashameah, Rami Adel, Alzahrani, Eman, Farouk, Abd-ElAziem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657098/
https://www.ncbi.nlm.nih.gov/pubmed/36364195
http://dx.doi.org/10.3390/molecules27217368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657098/
https://www.ncbi.nlm.nih.gov/pubmed/36364195
http://dx.doi.org/10.3390/molecules27217368

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