The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity

Sphingosine kinases type 1 and 2 (SphK1/2) are required for the production of the immune modulator sphingosine 1-phosphate (S1P). SphK1 deficient mice (SphK1(−/−)) revealed 50% reduced S1P in plasma, while SphK2(−/−) mice demonstrated 2–3 times increased S1P levels in plasma. Since plasma S1P is a p...

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Detalles Bibliográficos
Autores principales: Thuy, Andreas V., Reimann, Christina-Maria, Ziegler, Anke C., Gräler, Markus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657211/
https://www.ncbi.nlm.nih.gov/pubmed/36361636
http://dx.doi.org/10.3390/ijms232112848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657211/
https://www.ncbi.nlm.nih.gov/pubmed/36361636
http://dx.doi.org/10.3390/ijms232112848

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