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The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity
Sphingosine kinases type 1 and 2 (SphK1/2) are required for the production of the immune modulator sphingosine 1-phosphate (S1P). SphK1 deficient mice (SphK1(−/−)) revealed 50% reduced S1P in plasma, while SphK2(−/−) mice demonstrated 2–3 times increased S1P levels in plasma. Since plasma S1P is a p...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657211/ https://www.ncbi.nlm.nih.gov/pubmed/36361636 http://dx.doi.org/10.3390/ijms232112848 |