Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics

Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as empagliflozin, lower blood glucose in type 2 diabetes mellitus and improve cardiorenal outcomes regardless of diabetes presence. Whether SGLT2is exert any effects on the brain’s metabolism has not been studied. We conducted a single-arm cl...

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Detalles Bibliográficos
Autores principales: Avgerinos, Konstantinos I., Mullins, Roger J., Vreones, Michael, Mustapic, Maja, Chen, Qinghua, Melvin, Denise, Kapogiannis, Dimitrios, Egan, Josephine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657243/
https://www.ncbi.nlm.nih.gov/pubmed/36359767
http://dx.doi.org/10.3390/cells11213372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657243/
https://www.ncbi.nlm.nih.gov/pubmed/36359767
http://dx.doi.org/10.3390/cells11213372

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