Cargando…

Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics

Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as empagliflozin, lower blood glucose in type 2 diabetes mellitus and improve cardiorenal outcomes regardless of diabetes presence. Whether SGLT2is exert any effects on the brain’s metabolism has not been studied. We conducted a single-arm cl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avgerinos, Konstantinos I., Mullins, Roger J., Vreones, Michael, Mustapic, Maja, Chen, Qinghua, Melvin, Denise, Kapogiannis, Dimitrios, Egan, Josephine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9657243/ https://www.ncbi.nlm.nih.gov/pubmed/36359767 http://dx.doi.org/10.3390/cells11213372

Ejemplares similares

Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer’s Disease and Inhibitors of Amyloid Formation
por: Liu, Qing-Rong, et al.
Publicado: (2023)

Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
por: Vreones, Michael, et al.
Publicado: (2022)

Elevated excitatory neurotransmitter levels in the fibromyalgia brain
por: Harris, Richard E
Publicado: (2010)

Diabetic Ketosis Caused by the Insulin Analog Aspart–Induced Anti-Insulin Antibody: Successful Treatment With the Newest Insulin Analog Glulisine
por: Yanai, Hidekatsu, et al.
Publicado: (2011)

Excitatory neurotransmitters in brain regions in interictal migraine patients
por: Prescot, Andrew, et al.
Publicado: (2009)

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II
por: Alvino, Clair L., et al.
Publicado: (2011)

Multitissue Insulin Resistance Despite Near-Normoglycemic Remission in Africans With Ketosis-Prone Diabetes
por: Choukem, Simeon-Pierre, et al.
Publicado: (2008)

Case Report: Efficient Avoidance of Hospitalization for Diabetic Ketosis Utilizing Technosphere Inhaled Insulin
por: Bell, David S. H., et al.
Publicado: (2020)

A Pediatric Case of Ketosis-Prone Type 2 Diabetes Requiring Insulin Therapy
por: Matsuura, Misa, et al.
Publicado: (2022)

Modeling the glutamate–glutamine neurotransmitter cycle
por: Shen, Jun
Publicado: (2013)

Glutamate as a neurotransmitter in the healthy brain
por: Zhou, Y., et al.
Publicado: (2014)

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease
por: Mullins, Roger J., et al.
Publicado: (2017)

Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics
por: Yu, Alvin, et al.
Publicado: (2018)

LBODP035 When Is Ketosis Just Ketosis?
por: Cannon, Sophie M, et al.
Publicado: (2022)

A Fasting Insulin–Raising Allele at IGF1 Locus Is Associated with Circulating Levels of IGF-1 and Insulin Sensitivity
por: Mannino, Gaia Chiara, et al.
Publicado: (2013)

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718
por: Andersen, Mie, et al.
Publicado: (2017)

Predictive Low-Glucose Insulin Suspension Reduces Duration of Nocturnal Hypoglycemia in Children Without Increasing Ketosis
por: Buckingham, Bruce A., et al.
Publicado: (2015)

Management of diabetic ketosis and ketoacidosis with intramuscular regular insulin in a low-resource family medicine setting
por: Basetty, Sudhakar, et al.
Publicado: (2017)

Combination therapy in type 2 diabetes mellitus: adding empagliflozin to basal insulin
por: Ahmann, Andrew
Publicado: (2015)

Anti-inflammatory effects of empagliflozin in patients with type 2 diabetes and insulin resistance
por: Hattori, Sachiko
Publicado: (2018)

PTPσ Controls Presynaptic Organization of Neurotransmitter Release Machinery at Excitatory Synapses
por: Han, Kyung Ah, et al.
Publicado: (2020)

Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters
por: Huang, Chun-Ping, et al.
Publicado: (2019)

Neurotransmitters regulate β cells insulin secretion: A neglected factor
por: Kong, Chu-Chu, et al.
Publicado: (2023)

Disrupting Insulin and IGF Receptor Function in Cancer
por: Cao, Jingran, et al.
Publicado: (2021)

Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes
por: Ma, Zhulin, et al.
Publicado: (2014)

Molecular Characterisation of Long-Acting Insulin Analogues in Comparison with Human Insulin, IGF-1 and Insulin X10
por: Hansen, Bo F., et al.
Publicado: (2012)

The Role of the Endocrine Glands in Ketosis—I. The Ketosis of Fasting
por: Amatruda, Thomas T., et al.
Publicado: (1959)

Ketosis-Onset Diabetes and Ketosis-Prone Diabetes: Same or Not?
por: Liu, Beiyan, et al.
Publicado: (2013)

Concentrations of Insulin Glargine and Its Metabolites During Long-Term Insulin Therapy in Type 2 Diabetic Patients and Comparison of Effects of Insulin Glargine, Its Metabolites, IGF-I, and Human Insulin on Insulin and IGF-I Receptor Signaling
por: Varewijck, Aimee J., et al.
Publicado: (2013)

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA
por: Schousboe, Arne, et al.
Publicado: (2013)

Modulation of anti-tumor lymphocyte function by neurotransmitter glutamate
por: Hodo, Thomas, et al.
Publicado: (2014)

Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake
por: Armbruster, Moritz, et al.
Publicado: (2020)

Effects of Intravenous Glucose Load on Insulin Secretion in Patients With Ketosis-Prone Diabetes During Near-Normoglycemia Remission
por: Gosmanov, Aidar R., et al.
Publicado: (2010)

Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
por: Li, Qian, et al.
Publicado: (2019)

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans
por: Viola, Cristina M., et al.
Publicado: (2023)

The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
por: Fahien, Leonard A., et al.
Publicado: (2011)

Empagliflozin/insulin/sodium bicarbonate: Euglycaemic diabetic ketoacidosis and lack of efficacy: case report
Publicado: (2022)

Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
por: Radlinger, Bernhard, et al.
Publicado: (2022)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin
por: Slaaby, Rita
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_foj3lg9p3dn9i70frhdppmtmmh